Farzan Nadim, PhD, is a professor in the department of mathematical sciences at New Jersey Institute of Technology. The main focus of Nadim´s research is to understand how synaptic dynamics, such as short-term depression and facilitation contribute to the generation and control of oscillatory neuronal activity. Such synaptic dynamics are found ubiquitously in all parts of the nervous systems.
Nadim´s research has helped identify new mechanisms through which a fast and a slow oscillatory network coordinate their activities. Elucidating mechanisms through which non-identical networks interact will help us understand, at a cellular and network level, how widespread synchronous patterns arise in large non-homogeneous networks, such as the brain. Such widespread synchronization of rhythmic activity among networks of neurons that normally function to produce distinct behavior can lead to disorders such as generalized epilepsy and Parkinson´s disease.
- Northeastern University, B.A., 1987.
- Boston University, M.A., 1989.
- Boston University, Ph.D., 1994.
Awards and Grants
National Institutes of Health MH-60605 (Principal Investigator) December 2000 (-2011)
Regulation of Neuronal Oscillations by Synaptic Dynamics
- Department of Mathematical Sciences, New Jersey Institute of Technology , Newark, NJ.
- Federated Department of Biological Sciences, NJIT/Rutgers University, Newark, NJ.
Cycle Director Stomatogastric Nervous System Cycle, Neural Systems and Behavior Course, Marine Biological Laboratory, Woods Hole, MA.
Member Center for Applied Mathematics and Statistics, New Jersey Institute of Technology, Newark, NJ.
Faculty Member Integrative Neuroscience Program, Rutgers University and University of Medicine and Dentistry of New Jersey, Newark, NJ.
I combine computational, analytical and experimental techniques towards understanding how properties of neurons and their synaptic dynamics shape the output of oscillatory neuronal networks. In particular, our laboratory studies the generation of rhythmic motor patterns in the crustacean stomatogastric nervous system (STNS). These rhythmic patterns are responsible for chewing and digestion of food in the intact animal, but persist in an acutely isolated nervous system in vitro.
The main focus of my research is to understand how synaptic dynamics, such as short-term depression and facilitation contribute to the generation and control of oscillatory neuronal activity. Such synaptic dynamics are found ubiquitously in all parts of the nervous systems. My modeling approach is to use geometric dynamical systems to follow the global behavior of models of neurons and small networks and, at the same time, to build biophysically realistic computer models of the system under study. Experiments in our lab involve characterization of the synaptic dynamics in the STNS and studying the contribution of these dynamics to network output in the biological network.
Zhang Y, Bose A and Nadim F: Predicting the activity phase of a follower neuron with A-current in an inhibitory network, Biological Cybernetics, 2008, In Press.
Clewley R, Soto-Trevino C and Nadim F: Dominant ionic mechanisms explored in spiking and bursting using local low-dimensional reductions of a biophysically realistic model neuron, J Computat Neurosci, 2008, In Press. Click for Abstract (Full text at http://dx.doi.org/10.1007/s10827-008-0099-1)
Mouser C, Nadim F and Bose A: Maintaining phase of the crustacean tri-phasic pyloric rhythm, J Math Biology, 57: 161-181, 2008. Click for Abstract
Blitz, D, White RS, Saideman SR, Cook A, Christie A, Nadim F and Nusbaum MP: A newly identified extrinsic input triggers a distinct gastric mill rhythm via activation of modulatory projection neurons, J Exp Biol, 211: 1000-1011, 2008. Click for Abstract
Kintos N, Nusbaum MP and Nadim F: Comparing projection neuron and neuromodulator-elicited oscillations in a motor network, J Comput Neurosci, 24: 374-397, 2008. Click for Abstract (Full text at http://dx.doi.org/10.1007/s10827-007-0061-7).Rotstein H and Nadim F (2007) Neurons and Neural Networks: Computational Models. In Encyclopedia of Life Sciences, John Wiley & Sons, Ltd: Chichester http://www.els.net, doi: 10.1002/9780470015902.a0000089.pub2.
Gansert J, Golowasch J and Nadim F: Sustained rhythmic activity in gap-junctionally coupled neurons depends on the diameter of coupled dendrites, 98:3450-3460, 2007. Click for Abstract (Full text at http://dx.doi.org/10.1152/jn.00648.2007).
Matveev V, Bose A and Nadim F: Describing the bursting dynamics of a two-cell inhibitory network using a one-dimensional map, J Computational Neuroscience, 23: 169-187, 2007.(Full text at http://dx.doi.org/10.1007/s10827-007-0026-x)
Nadim F and Bose A: Dynamics of Central Pattern Generating Networks: Locus of Control, SIAM News: Vol 40 No 2, p 151, 2007. (in pdf form)