The goal of the Golowasch lab research is to understand the mechanisms that allow the nervous system to be simultaneously plastic, and thus responsive to environmental and internal changes, and stable.
His work is based on the assumption that simultaneous stability and plasticity can only come about when neurons globally adjust their properties as they locally make adaptive changes to specific conditions and perturbations. What are the rules that are required for these two properties to be expressed simultaneously? What are the biological mechanisms (cellular, molecular) that make this possible? Neuronal activity itself, the neuromodulatory environment, and circadian activity and perhaps sleep seem to be crucial factors.
In my work I apply experimental (electrophysiology, cell and molecular biology) and theoretical (analytical and computational) approaches and methods.
The main experimental animal we use is the local crab, Cancer borealis, cell lines, and acutely dissociated cells in culture, and we are starting to use mouse brain slices.